Ultrafast synthesis of stabilized gold nanoparticles using aqueous fruit extract of Limonia acidissima L. and conjugated epirubicin: targeted drug delivery for treatment of breast cancer
作者： C. Senthil Kumar , Ayyavu Mahesh , M. Gover Antoniraj , S. Vaidevi , K. Ruckmani
DOI: 10.1039/C6RA01482H
关键词: Conjugated system 、 Analytical chemistry 、 Aqueous solution 、 Limonia acidissima 、 Chemistry 、 Nuclear chemistry 、 Zeta potential 、 Targeted drug delivery 、 In vitro 、 Colloidal gold 、 Surface plasmon resonance
摘要: In this study, a green chemistry approach was used for the quick synthesis (within 30 seconds) of gold nanoparticles (AuNPs) by using fruit extract Limonia acidissima L. The study focused on formation stabilized AuNPs without any catalytic agent. confirmed observation surface plasmon resonance (SPR) band at 537 nm. On these capped AuNPs, epirubicin (EPI) conjugated along with activated folic acid (FA) targeted drug delivery. EPI–FA–AuNPs complex characterized FTIR and UV-visible spectrophotometer were HR-TEM, particle size analyzer, zeta potential measurements. vitro stability experiments revealed that stable in physiological conditions. cytotoxicity free EPI investigated against MCF-7 cells, results showed 50% enough to achieve inhibition growth (IC50) amount lower than EPI. Flow cytometry analysis significant reduction G2/M cells after treatment EPI–FA–AuNPs, molecular levels apoptosis studied western blotting. Overall, have better regression activity tumor
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