Biochemistry of the Endogenous Ligands of Cannabinoid Receptors
作者： Vincenzo Di Marzo , Dale G. Deutsch
关键词: Cannabinoid receptor type 1 、 Biochemistry 、 Depolarization-induced suppression of inhibition 、 Anandamide 、 GPR119 、 Endocannabinoid system 、 Cannabinoid receptor type 2 、 Chemistry 、 GPR18 、 Cannabinoid receptor
摘要: Abstract In 1992 the discovery of first endogenous ligand cannabinoid receptors, anandamide, provided conclusive support to hypothesis that an “endogenous regulatory system” exists in mammalian nervous tissue. Anandamide (N-arachidonoyl-ethanolamine) was a series long-chain fatty acid derivatives, including two other polyunsaturatedN-acylethanolamines and 2-arachidonoyl-glycerol, found exert cannabimimetic properties either central or peripheral tissues. Here we review current knowledge on biochemical bases formation inactivation ligands as well their interaction with receptor subtypes.
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