Germ cell tumors (II). VAB II in metastatic testicular cancer

摘要: Between June 1974 and January 1976, 50 patients with metastatic nonseminometous testicular carcinoma were treated the V AB II protocol. The induction phase consisted of vinblastine (0.4 mg/kg) actinomycin D (0.02 on day 1. Bleomycin (0.5 was given by continuous infusion for 7 days, cis-diammine-dichloroplatinum (II) (DDP) (1 8. A weekly maintenance bleomycin, DDP a rotating schedule followed vinblastine, chlorambucil every 3–4 weeks. Therapy discontinued after 30–36 months treatment in face continued remission. response rate 50% CR, 34% PR 60% CR 36% previously untreated patients. Second-look surgery excision residual lesions performed selected cases. Alopecia, mucositis, nausea, vomiting universal. One patient died postsurgical period toxicity from combination bleomycin high concentrations oxygen. There seven instances allergic reactions to DDP. Eleven 25 complete responders 4 partial or minor who underwent stable disease remain alive 19 35 following start therapy, 12 them without evidence disease. Cancer 42:2162–2168, 1978.