Measurement of density variations in tablets using X-ray computed tomography.
作者： I.C. Sinka , S.F. Burch , J.H. Tweed , J.C. Cunningham
DOI: 10.1016/J.IJPHARM.2003.11.022
关键词: Energy (signal processing) 、 Material density 、 Optics 、 Attenuation 、 X-ray 、 Materials science 、 Measure (physics) 、 Beam hardening 、 X ray computed 、 Tomography
摘要: In this paper the application of X-ray computed tomography (CT) to measure material density distribution in pharmaceutical tablets is discussed. CT a non-destructive inspection technique which provides cross-sectional images different planes through component. The image values provide information on local attenuation coefficients. For particular and energy, approximately proportional density. Determination quantitative distributions requires consideration non-linear instrumental effects including scatter "beam hardening". Density maps manufactured under controlled conditions are presented. results discussed with reference properties within tablet design features.
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