Rolle von Levosimendan in der intensivmedizinischen Behandlung des myokardialen Pumpversagens
作者： S. Rehberg , C. Ertmer , H. Van Aken , M. Lange , K. Bröking
DOI: 10.1007/S00101-006-1108-2
关键词: Calcium sensitizer 、 Myocardial ischemia 、 Intensive care 、 Cardiotonic Agents 、 Gynecology 、 Medicine
摘要: Der „Kalzium-Sensitizer“ Levosimendan steht aktuell im Blickpunkt der intensivmedizinischen Forschung, da er den klassischen Inotropika bei Therapie akut dekompensierten Herzinsuffizienz moglicherweise uberlegen ist. Seine Wirkung beruht Wesentlichen auf drei Mechanismen: 1) positive Inotropie durch die Sensibilisierung kardialen Myofilamente gegenuber Kalziumionen, 2) Vasodilatation Aktivierung adenosintriphosphatsensitiver Kaliumkanale und 3) Hemmung Phosphodiesterase-III. In zahlreichen experimentellen klinischen Untersuchungen sind weitere potenzielle Indikationen fur nachgewiesen worden: Kardioprotektion wahrend einer Ischamie, kardiogener Schock, septische Kardiomyopathie pulmonaler Hypertonus. Dieser Ubersichtsartikel stellt Pharmakologie, Wirkmechanismen mogliche Risiken von unter Berucksichtigung aktuellen Studienlage kritisch dar.
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Frank Isgro, Joachim Boldt, Johannes Lang, Andreas Lehmann, Arndt Holger Kiessling, Levosimendan in patients with cardiogenic shock undergoing surgical revascularization: a case series. Medical Science Monitor. ,vol. 10, ,(2004)
Hisashi Yokoshiki, Nicholas Sperelakis, Vasodilating mechanisms of levosimendan. Cardiovascular Drugs and Therapy. ,vol. 17, pp. 111- 113 ,(2003) , 10.1023/A:1025379400395
F.V. Shammas, K. Dickstein, Clinical pharmacokinetics in heart failure. An updated review. Clinical Pharmacokinectics. ,vol. 15, pp. 94- 113 ,(1988) , 10.2165/00003088-198815020-00002
Masao Endoh, Mechanism of Action of Ca2+ Sensitizers—Update 2001 Cardiovascular Drugs and Therapy. ,vol. 15, pp. 397- 403 ,(2001) , 10.1023/A:1013385305567
E. Niclas Jonsson, Saila Antila, Lynn McFadyen, Lasse Lehtonen, Mats O. Karlsson, Population pharmacokinetics of levosimendan in patients with congestive heart failure. British Journal of Clinical Pharmacology. ,vol. 55, pp. 544- 551 ,(2003) , 10.1046/J.1365-2125.2003.01778.X
Burkert Pieske, Levosimendan in regional myocardial ischemia. Cardiovascular Drugs and Therapy. ,vol. 16, pp. 379- 381 ,(2002) , 10.1023/A:1022199932485
F Turani, P Aurisicchio, P D'Ercole, Hemodynamic and volumetric response to levosimendan in critical care patients. Critical Care. ,vol. 8, pp. 84- ,(2004) , 10.1186/CC2551
MA Carter, MC Blunt, Screening and isolation of methicillin-resistant Staphylococcus aureus (MRSA) colonized patients is widely practiced in UK critical care units but little benefit is perceived Critical Care. ,vol. 6, pp. 84- ,(2002) , 10.1186/CC1788
Endorsed by the European Society of Intensive Care Medicine (ESICM), Authors/Task Force Members, Markku S Nieminen, Michael Böhm, Martin R Cowie, Helmut Drexler, Gerasimos S Filippatos, Guillaume Jondeau, Yonathan Hasin, José Lopez-Sendon, Alexandre Mebazaa, Marco Metra, Andrew Rhodes, Karl Swedberg, ESC Committee for Practice Guidelines (CPG), Silvia G Priori, Maria Angeles Alonso Garcia, Jean-Jacques Blanc, Andrzej Budaj, Martin R Cowie, Veronica Dean, Jaap Deckers, Enrique Fernandez Burgos, John Lekakis, Bertil Lindahl, Gianfranco Mazzotta, João Morais, Ali Oto, Otto A Smiseth, Document Reviewers, Maria Angeles Alonso Garcia, Kenneth Dickstein, Anibal Albuquerque, Pedro Conthe, Maria Crespo-Leiro, Roberto Ferrari, Ferenc Follath, Antonello Gavazzi, Uwe Janssens, Michel Komajda, João Morais, Rui Moreno, Mervyn Singer, Satish Singh, Michal Tendera, Kristian Thygesen, None, Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology. European Heart Journal. ,vol. 26, pp. 384- 416 ,(2005) , 10.1093/EURHEARTJ/EHI044
Peggy Bowman, Richard J. Paul, Heimo Haikala, Levosimendan, a Calcium Sensitizer in Cardiac Muscle, Induces Relaxation in Coronary Smooth Muscle Through Calcium Desensitization Journal of Pharmacology and Experimental Therapeutics. ,vol. 288, pp. 316- 325 ,(1999)