Diagnosis and management of hypersensitivity reactions related to common cancer chemotherapy agents
作者： Christina Lee , Mary Gianos , William B. Klaustermeyer
DOI: 10.1016/S1081-1206(10)60078-6
关键词: Oncology 、 Immunology 、 Procarbazine 、 Oxaliplatin 、 Internal medicine 、 Chemotherapy 、 Carboplatin 、 Taxane 、 Docetaxel 、 Asparaginase 、 Premedication 、 Medicine 、 Immunology and Allergy 、 Pulmonary and Respiratory Medicine
摘要: Objectives To review clinical hypersensitivity reactions related to common cancer chemotherapy agents and discuss potential management strategies. Data Sources PubMed searches were performed for articles published from 1970 2008 regarding using the keywords hypersensitivity, allergy, chemotherapy, platinums, taxanes, asparaginase, epipodophyllotoxins , procarbazine . Retrieved surveyed additional citations. Study Selection Articles reviewed relevance subject matter, most pertinent included in this review. Results Hypersensitivity are commonly associated with use of certain drugs, including procarbazine, epipodophyllotoxins. Platinum (cisplatin, carboplatin, oxaliplatin) IgE-mediated reactions, skin testing may be indicated. Taxane (paclitaxel, docetaxel)-related generally non-IgE mediated, premedication corticosteroids antihistamines is usually effective. Asparaginase has a high rate that likely IgE mediated or complement activation. Skin been recommended but not validated asparaginase. Procarbazine can also type III reaction manifested by pulmonary toxicity cutaneous reactions. involve both immunologic nonimmunologic factors avoided slow infusion premedication. Conclusion With increasing agents, encountered. Knowledge presentations these options give treating physician means make an informed decision how best proceed.
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