An efficient synthesis of varenicline
作者： Srinivas Pasikanti , D. Srinivasa Reddy , B. Venkatesham , P.K. Dubey , Javed Iqbal
DOI: 10.1016/J.TETLET.2009.10.107
关键词: Yield (chemistry) 、 Organic chemistry 、 Oxidative cleavage 、 Olefin fiber 、 Reductive amination 、 Chemistry 、 Varenicline 、 Biochemistry 、 Drug discovery
摘要: Abstract Synthesis of varenicline the antismoking drug has been achieved in six steps with 10% overall yield. A Diels–Alder reaction, oxidative cleavage an olefin and reductive amination remain as key synthesis
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