Elevated Plasma Procaine Concentrations after Administration of Procaine Penicillin G

作者: Richard L. Green , John E. Lewis , Stephen J. Kraus , Evan L. Frederickson

DOI: 10.1056/NEJM197408012910503

关键词: Million UnitsProcaineMedicineProcaine penicillin GPopulationAnesthesiaGeneral Medicine

摘要: Abstract Plasma procaine concentrations were measured in 26 patients immediately after the intramuscular administration of 4.8 million units penicillin G for treatment gonorrhea. The values ranged from 3.6 to 11.0 μg per milliliter. Three different lots also checked presence free bottles stored at 4°C. 8.3 milliliter and increased with storage room temperature or heating 56°C. These levels probably account high frequency (0.9 cent our clinic population) abnormal behavioral neurologic reactions that occur G. Although was found three 4°C, though these higher temperatures, small amounts mixture under physical conditions not a prerequisite inducement syndrome. Therefore, instantaneous libe...

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