Biological basis of depression and therapeutic relevance.

摘要: Before the advent of pharmacologic treatment depression, there were theories about biological basis affective disorders. However, today's are derived largely from known effects antidepressants. These effects, neurochemical studies with laboratory animals, have implicated catecholamines and serotonin in depression. Although most antidepressant drugs use today been available for decades, their mechanism action treating depression has not established. In addition, causes proven. Nevertheless, rich pharmacology involving blockade neuronal uptake systems some biogenic amines many receptors neurotransmitters can explain adverse certain interactions other drugs.