Polymeric delivery formulations of leuprolide with improved efficacy

作者: Harish Ravivarapu , Bhagya L. Chandrashekar , John Steven Garrett , Richard L. Dunn

DOI:

关键词: Materials scienceBiocompatible materialControlled releaseAqueous mediumOrganic chemistrySolventPolyesterThermoplastic

摘要: The present invention is directed to a flowable composition that suitable for use as controlled release implant. includes biodegradable thermoplastic polyester at least substantially insoluble in aqueous medium or body fluid. also biocompatible polar aprotic solvent. solvent miscible dispersible leuprolide acetate.

参考文章(48)
Spencer J. Speer, Packaging and dispensing kit ,(1976)
Fritz Hostettler, Harry Vineyard, Process for the preparation of lactone polyesters ,(1963)
John R. Peery, Jeremy C. Wright, James B. Eckenhoff, Judy A. Magruder, Scott D. Lautenbach, Felix A. Landrau, Keith E. Dionne, Sustained delivery of leuprolide using an implantable system ,(1997)
Muneo Nonomura, Tomomichi Futo, Hisayoshi Shimizu, Pharmaceutical product for application to uterus mucosa ,(1998)
Peter G. M. Wuts, Theodora W. Greene, Protective groups in organic synthesis ,(1981)
Minoru Yamada, Yasuaki Ogawa, Shigeru Kamei, Method of producing sustained-release microcapsules ,(1993)
Francis Gowland Hutchinson, Continuous release pharmaceutical compositions ,(1982)
Hosei Shinoda, Masanobu Ajioka, Kimitaka Chida, Bioabsorbable polymer and process for preparing the same ,(1996)