Cost-effectiveness analysis alongside a pilot study of prophylactic negative pressure wound therapy

摘要: Abstract Background Negative pressure wound therapy (NPWT) is increasingly used prophylactically following surgery despite limited evidence of clinical or cost-effectiveness. Objective To evaluate whether NPWT cost-effective compared to standard care, for the prevention surgical site infection (SSI) in obese women undergoing elective caesarean section, and inform development a larger trial. Methods An economic evaluation was conducted alongside pilot randomised controlled trial at one Australian hospital, which were (n = 44) care (n = 43). A public health provider perspective time horizon four weeks post-discharge adopted. Cost-effectiveness assessment based on incremental cost per SSI prevented quality-adjusted life year (QALY) gained. Results Patients receiving each received costing AU$5887 (±1038) reported 0.069 (±0.010) QALYs AU$5754 (±1484) 0.066 patients care. may be slightly more costly effective than with estimated cost-effectiveness ratios (ICERs) AU$1347 (95%CI dominant- $41,873) AU$42,340 $884,019) QALY However, there considerable uncertainty around these estimates. Conclusions prophylactic treatment wounds section women. Larger trials could clarify as SSI. Sensitive capture offsets will important given high level point estimate ratio close conventional thresholds. New Zealand registration number ACTRN12612000171819.