Full-Breadth Analysis of CD8+ T-Cell Responses in Acute Hepatitis C Virus Infection and Early Therapy

摘要: Multispecific CD8+ T-cell responses are thought to be important for the control of acute hepatitis C virus (HCV) infection, but date little information is actually available on breadth at early time points. Additionally, influence therapy these and their relationships outcome controversial. To investigate this issue, we performed comprehensive analysis frequencies virus-specific single epitope level in eight acutely infected individuals who were all started therapy. During phase, against up five peptides identified. therapy, decreased rather than increased as was controlled, no new specificities emerged. A sustained virological response following completion treatment independent responses, well CD4+ responses. Rapid recrudescence also occurred despite broad Importantly, vivo suppression CD3+ T cells using OKT3 one subject did not result recurrence viremia. These data suggest that alone may insufficient contain HCV replication, effective such