Intracisternal type A particle-mediated activation of the Notch4/int3 gene in a mouse mammary tumor: generation of truncated Notch4/int3 mRNAs by retroviral splicing events.
作者： Jong-Seo Lee , Tatsuya Haruna , Akinori Ishimoto , Tasuku Honjo , Shin-ichi Yanagawa
DOI: 10.1128/JVI.73.6.5166-5171.1999
关键词: Gene rearrangement 、 Intron 、 Molecular biology 、 Exon 、 Oncogene 、 RNA splicing 、 Biology 、 Long terminal repeat 、 Mammary tumor 、 Gene
摘要: The int3 oncogene was discovered as a frequent target in mouse mammary tumor virus-induced tumors and encodes the intracellular domain of Notch4/int3 protein. In one spontaneous tumor, no. 9, that developed BALB/c mouse, we have found an insertion 1.2-kb sequence, consisting 5′ long terminal repeat gag sequences intracisternal type A particle (IAP) well extra copy genomic containing exons 23 24, into intron between 24 25 gene. this unique splicing events IAP generated two types IAP- fusion transcripts encoding different portions proteins: with RAM other without. Interestingly, these proteins showed subcellular localizations epithelial cell line, HC-11.
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