Biological Variability in Concentrations of Serum Lipids: Sources of Variation Among Results From Published Studies and Composite Predicted Values
作者： S J Smith , G R Cooper , G L Myers , E J Sampson
DOI: 10.1093/CLINCHEM/39.6.1012
关键词: Animal science 、 Regression analysis 、 Cholesterol 、 Biochemistry 、 Biology 、 Meta-analysis 、 Blood lipids 、 Biological variation 、 Design characteristics 、 Biological variability 、 Triglyceride
摘要: To obtain the best estimates of average intraindividual biological variability (CVb) in concentrations total cholesterol (TC), low-density lipoprotein (LDLC), high-density (HDLC), and triglyceride serum lipids a person's blood, we evaluated results from 30 studies published 1970 to 1992. The usually more applicable random-effects model estimated an CVb 6.1% for TC, 7.4% HDLC, 9.5% LDLC, 22.6% triglyceride. Composite all by different models estimation ranged 6.0% 6.4% 6.2% 7.5% 7.0% 9.6% 22.4% 22.9% Two important factors influenced reported variation study subjects: (a) magnitude analytical method used (b) design characteristics study--primarily number subjects, sampling interval, measurements per subject. For found statistically significant positive correlation between mean both subjects variation. TC LDLC estimate as function features. patient specimens required reliable lipid are determined current
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