Direct Synthesis of Substituted Naphthalenes from 1,3-Dicarbonyl Compounds and 1,2-Bis(halomethyl)benzenes Including a Novel Rearrangement Aromatization of Benzo[c]oxepine
作者： Jun-gang Wang , Meng Wang , Jia-chen Xiang , Yan-ping Zhu , Wei-jian Xue
DOI: 10.1021/OL302950W
关键词: Cascade reaction 、 Chemistry 、 Benzene 、 Organic chemistry 、 Aromatization
摘要: An unexpected rearrangement aromatization of benzo[c]oxepine has been revealed to synthesize substituted naphthalenes. This observation was further exploited develop an efficient approach for the construction naphthalenes from simple and commercially available 1,3-dicarbonyl compounds 1,2-bis(halomethyl)benzene via a new domino reaction sequence.
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