Oral Cobalamin for Pernicious Anemia

摘要: THE TREATMENT of pernicious anemia with cobalamin is one medicine's great success stories. However, the usual practice giving drug as an intramuscular injection has several drawbacks. Injections can be painful, difficult to provide for some patients who are elderly or living alone, 1 and costly if given by health professionals. 2 It therefore not surprising that search oral preparation began soon after was isolated introduced parenteral use in 1948. Preparations containing intrinsic factor were tried, but antibody production caused become refractory relapse. 3 Other studies revealed a small constant proportion dose cyanocobalamin absorbed without factor, so sufficiently increasing dose, adequate absorption could attained. 4,5 Promising results from early therapy led increasingly larger doses,