High Risk of Brain Metastases in Surgically Staged IIIA Non–Small-Cell Lung Cancer Patients Treated With Surgery, Chemotherapy, and Radiation
作者： Harvey J. Mamon , Beow Yong Yeap , Pasi A. Jänne , Jason Reblando , Sarah Shrager
关键词: Respiratory disease 、 Surgery 、 Chemotherapy 、 Histology 、 Disease 、 Central nervous system disease 、 Non small cell 、 Medicine 、 Lung cancer 、 Stage (cooking)
摘要: Purpose Lung cancer is the leading cause of mortality in United States. We sought to review our experience with surgically staged IIIA (N2) non–small-cell lung (NSCLC), focusing on patterns failure consecutively treated patients from 1988 2000. Patients and Methods The records 177 were reviewed. Collected data included stage, histology, use chemotherapy radiation, initial subsequent sites failure, survival. One hundred twenty-four have died; follow-up time 35 months among remaining patients. Results median survival surgery was 21.0 months, a 3-year overall (OS) 34%. Nodal downstaging N0 disease correlated OS progression-free (PFS; P < .001). most common site recurrence brain. Thirty-four percent recurred brain as their first 40% developed metastases at some point course. In non...
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