Immune Reconstitution with Antiretroviral Chemotherapy

摘要: Infection with HIV-1 results in the progressive loss of CD4+ T-lymphocytes and a variety immune functions, leading ultimately to premature death most untreated individuals. The introduction potent combination antiretroviral chemotherapy for infection mid-1990s resulted unprecedented decreases replication increases T-cell counts many treated Simultaneous antiviral drug therapy, substantial declines morbidity mortality from HIV-1-associated illnesses have been observed. study reconstitution context viral suppression has already provided some important insights into pathogenesis HIV-1. Many questions remain, however, concerning extent clinical significance that occurs setting therapy.