Method and apparatus for rapid in situ analysis of preselected components of homogeneous solid compositions, especially pharmaceutical compositions

摘要: A method and apparatus for rapid in situ spectroscopic analysis of preselected components homogeneous solid chemical compositions, especially pharmaceutical products. The comprises a high-power pulsed laser (10) whose beam is focused on the material (18), typically tablet or powder prior to compaction into tablet, which generally consists an active ingredient (e.g. drug) filler (cellulose, glucose, lactose, etc.). vaporizes small volume product produces plasma having elemental composition representative product. atomic vaporized analyzed with optical spectrometer (24). As temperature sufficiently elevated cause dissociation molecules constituents product, concentration obtained by analyzing element present but not matrix material, substantially different from matrix, acts as tag material. technique can also be used analyze inactive ingredients presence unwanted contaminants consist elements normally such products trace metals introduced accidentally during processing.