Systems Biology Reveals NR2F6 and TGFB1 as Key Regulators of Feed Efficiency in Beef Cattle.

作者: Pâmela A. Alexandre , Marina Naval-Sanchez , Laercio R. Porto-Neto , José Bento S. Ferraz , Antonio Reverter

DOI: 10.3389/FGENE.2019.00230

关键词: Candidate geneSingle-nucleotide polymorphismResidual feed intakeSystems biologyComputational biologyBeef cattleRegulator geneBiologyPhenotypeGene

摘要: Systems biology approaches are used as strategy to uncover tissue-specific perturbations and regulatory genes related to complex phenotypes. We applied this approach to study feed …

参考文章(98)
R. M. Herd, V. H. Oddy, E. C. Richardson, Biological basis for variation in residual feed intake in beef cattle 1: Review of potential mechanisms Animal Production Science. ,vol. 44, pp. 423- 430 ,(2004) , 10.1071/EA02220
P. A. Lancaster, G. E. Carstens, J. J. Michal, K. M. Brennan, K. A. Johnson, M. E. Davis, Relationships between residual feed intake and hepatic mitochondrial function in growing beef cattle. Journal of Animal Science. ,vol. 92, pp. 3134- 3141 ,(2014) , 10.2527/JAS.2013-7409
Yi Cao, Zizhen Yao, Deepayan Sarkar, Michael Lawrence, Gilson J. Sanchez, Maura H. Parker, Kyle L. MacQuarrie, Jerry Davison, Martin T. Morgan, Walter L. Ruzzo, Robert C. Gentleman, Stephen J. Tapscott, Genome-wide MyoD Binding in Skeletal Muscle Cells: A Potential for Broad Cellular Reprogramming Developmental Cell. ,vol. 18, pp. 662- 674 ,(2010) , 10.1016/J.DEVCEL.2010.02.014
J. D. Nkrumah, D. H. Keisler, D. H. Crews, J. A. Basarab, Z. Wang, C. Li, M. A. Price, E. K. Okine, S. S. Moore, Genetic and phenotypic relationships of serum leptin concentration with performance, efficiency of gain, and carcass merit of feedlot cattle Journal of Animal Science. ,vol. 85, pp. 2147- 2155 ,(2007) , 10.2527/JAS.2006-764
Miguel HA Santana, Yuri T Utsunomiya, Haroldo HR Neves, Rodrigo C Gomes, José F Garcia, Heidge Fukumasu, Saulo L Silva, Gerson A Oliveira Junior, Pâmela A Alexandre, Paulo R Leme, Ricardo A Brassaloti, Luiz L Coutinho, Thiago G Lopes, Flávio V Meirelles, Joanir P Eler, Jose Ferraz, None, Genome-wide association analysis of feed intake and residual feed intake in Nellore cattle BMC Genetics. ,vol. 15, pp. 21- 21 ,(2014) , 10.1186/1471-2156-15-21
M. H. Ramos, M. S. Kerley, Mitochondrial complex I protein differs among residual feed intake phenotype in beef cattle Journal of Animal Science. ,vol. 91, pp. 3299- 3304 ,(2013) , 10.2527/JAS.2012-5589
C.V. Gonano, Y.R. Montanholi, F.S. Schenkel, B.A. Smith, J.P. Cant, S.P. Miller, The relationship between feed efficiency and the circadian profile of blood plasma analytes measured in beef heifers at different physiological stages Animal. ,vol. 8, pp. 1684- 1698 ,(2014) , 10.1017/S1751731114001463
Erin E Connor, Stanislaw Kahl, Theodore H Elsasser, Joel S Parker, Robert W Li, Curtis P Van Tassell, Ransom L Baldwin, Scott M Barao, None, Enhanced mitochondrial complex gene function and reduced liver size may mediate improved feed efficiency of beef cattle during compensatory growth Functional & Integrative Genomics. ,vol. 10, pp. 39- 51 ,(2010) , 10.1007/S10142-009-0138-7
J. A. Archer, E. C. Richardson, R. M. Herd, P. F. Arthur, Potential for selection to improve efficiency of feed use in beef cattle: a review Crop & Pasture Science. ,vol. 50, pp. 147- 162 ,(1999) , 10.1071/A98075