Association between testosterone, estradiol and sex hormone binding globulin levels in men with type 1 diabetes with nephropathy.

摘要: Male sex is a risk factor for development and progression of diabetic nephropathy; however, the relationship between hormone levels nephropathy in type 1 men unknown. This was prospective follow-up study as part nationwide Finnish Diabetic Nephropathy (FinnDiane) Study; 297 patients were followed 5.9 ± 1.5 years. Serum total testosterone (Tt) estradiol (Te), calculated free (cFt) (cFe) binding globulin measured at baseline correlated with urinary albumin excretion rate, estimated glomerular filtration rate markers metabolic syndrome. Diabetes without renal disease associated decreased Tt (p < 0.001), Te 0.001) cFt (p=0.001) compared healthy non-diabetic men. With from micro- to macroalbuminuria, this decrease serum even more pronounced. Cox regression showed that cFe independent predictors macroalbuminuria end-stage disease. Our shows diabetes exhibit dysregulated levels, which most pronounced progressive disease, suggesting hormones may play role pathogenesis diabetes.