Patients with Wiskott-Aldrich syndrome have normal IgG2 levels.

摘要: The Wiskott-Aldrich Syndrome (WAS) in humans has a number of similarities to the immunodeficiencies found CBA/N mice, including X-chromosome-linked inheritance, inability produce antibodies various carbohydrate antigens, susceptibility bacterial infections, and an imbalance B lymphocyte subpopulations. Moreover, both man IgG polysaccharides are predominantly, but not exclusively, restricted single subclass--IgG2 man, IgG3 mouse. Because mice have deficiency because human IgG2 subclass deficiencies been generally associated with it would seem likely that patients WAS greatly reduced levels IgG2. Quite contrary, data presented here demonstrate normal different subclasses, Thus, carbohydrates is always deficiency.