Therapeutic potential for coxibs-nitric oxide releasing hybrids in cystic fibrosis
作者： Sara Consalvi , Giovanna Poce , Carla Ghelardini , Lorenzo Di Cesare Mannelli , Paola Patrignani
DOI: 10.1016/J.EJMECH.2020.112983
关键词: Inflammation 、 Chemistry 、 Airway inflammation 、 Cystic fibrosis 、 Nitric oxide 、 Arthritis 、 Pharmacokinetics 、 Pharmacology 、 Pharmacological treatment
摘要: Abstract This review discusses the rational for further studies of COX-2 inhibitors-NO releaser hybrids (NO-Coxibs) in pharmacological treatment airway inflammation Cystic Fibrosis (CF). Our research group developed several classes NO-Coxibs arthritis, and among them compounds showed an outstanding in vivo efficacy good pharmacokinetic properties. The antiinflammatory properties displayed by these during previous screening could, itself, suggest appropriate candidates testing CF.
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