Specific effect of corticoids on acetylcholine receptor expression in rat skeletal muscle cell cultures.

摘要: The potential effect of different classes steroids on the expression acetylcholine receptors (AChR) was studied in primary cultures newborn-rat skeletal muscle cells. Comparison among three techniques for preparing newborn cells showed that these systems were equivalent to study AChR expression. Only corticoids stimulated myogenesis as a twofold increase indicated. Among corticoids, glucocorticoids more potent, whereas mineralocorticoid aldosterone had less marked effect. sex hormones progesterone and testosterone partially blocked effects, without inducing any significant when given alone. tested differed efficacy correlation with their chemical structures. clear structure-activity relationship could be established. These results emphasize specificity corticoid action suggest an explanation effects induced by used treating human muscular or neuromuscular diseases.