Raman study of impurity influence on active center in artemisinin.
作者： Hua-Yi Hou , Xin Yang , Zhong-Liang Mao , Xi-Yu Yao , Xiang-Bai Chen
DOI: 10.1016/J.SAA.2019.117206
关键词: Artemisinin 、 Molecular vibration 、 Analytical chemistry 、 Chemistry 、 Active center 、 Homogeneity (physics) 、 Impurity 、 Raman spectroscopy 、 Molecule 、 Raman imaging
摘要: Abstract The unusual endoperoxide bridge is believed to be the active center for artemisinin activations. Our Raman study indicated that more significantly influenced by impurity than other parts in molecule. This phenomenon provides a spectroscopy method quantitative measurement of content basing on relative intensity ratio analysis characteristic vibrational modes. proposed can good alternative high performance liquid chromatography, which commonly applied technique measuring content. Also, provide additional information homogeneity. In addition, imaging presented easy visualization and homogeneity simultaneously.
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sci-hub.se 参考文章(36)
Laura Moroni, Cristina Gellini, Maurizio Muniz Miranda, Pier Remigio Salvi, Maria Luisa Foresti, Massimo Innocenti, Francesca Loglio, Emanuele Salvietti, Raman and infrared characterization of the vibrational properties of the antimalarial drug artemisinin Journal of Raman Spectroscopy. ,vol. 39, pp. 276- 283 ,(2008) , 10.1002/JRS.1880
I. Noda, Generalized Two-Dimensional Correlation Method Applicable to Infrared, Raman, and other Types of Spectroscopy: Applied Spectroscopy. ,vol. 47, pp. 1329- 1336 ,(1993) , 10.1366/0003702934067694
Jian-De Gu, Kai-Xian Chen, Hua-Liang Jiang, Wei-Liang Zhu, Jian-Zhong Chen, Ru-Yun Ji, A quantum chemistry study of Qinghaosu Chemical Physics Letters. ,vol. 277, pp. 234- 238 ,(1997) , 10.1016/S0009-2614(97)00877-4
C. J. Paddon, P. J. Westfall, D. J. Pitera, K. Benjamin, K. Fisher, D. McPhee, M. D. Leavell, A. Tai, A. Main, D. Eng, D. R. Polichuk, K. H. Teoh, D. W. Reed, T. Treynor, J. Lenihan, H. Jiang, M. Fleck, S. Bajad, G. Dang, D. Dengrove, D. Diola, G. Dorin, K. W. Ellens, S. Fickes, J. Galazzo, S. P. Gaucher, T. Geistlinger, R. Henry, M. Hepp, T. Horning, T. Iqbal, L. Kizer, B. Lieu, D. Melis, N. Moss, R. Regentin, S. Secrest, H. Tsuruta, R. Vazquez, L. F. Westblade, L. Xu, M. Yu, Y. Zhang, L. Zhao, J. Lievense, P. S. Covello, J. D. Keasling, K. K. Reiling, N. S. Renninger, J. D. Newman, High-level semi-synthetic production of the potent antimalarial artemisinin Nature. ,vol. 496, pp. 528- 532 ,(2013) , 10.1038/NATURE12051
Sofia Kapetanaki, Constantinos Varotsis, Fourier transform infrared investigation of non-heme Fe(III) and Fe(II) decomposition of artemisinin and of a simplified trioxane alcohol. Journal of Medicinal Chemistry. ,vol. 44, pp. 3150- 3156 ,(2001) , 10.1021/JM010848D
Richard K. Haynes, Wing Chi Chan, Chung-Man Lung, Anne-Catrin Uhlemann, Ursula Eckstein, Donatella Taramelli, Silvia Parapini, Diego Monti, Sanjeev Krishna, The Fe2+-mediated decomposition, PfATP6 binding, and antimalarial activities of artemisone and other artemisinins: the unlikelihood of C-centered radicals as bioactive intermediates. ChemMedChem. ,vol. 2, pp. 1480- 1497 ,(2007) , 10.1002/CMDC.200700108
Mustapha Hajjou, Yanyan Qin, Sanford Bradby, Daniel Bempong, Patrick Lukulay, Assessment of the performance of a handheld Raman device for potential use as a screening tool in evaluating medicines quality. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 74, pp. 47- 55 ,(2013) , 10.1016/J.JPBA.2012.09.016
U. Eckstein-Ludwig, R. J. Webb, I. D. A. van Goethem, J. M. East, A. G. Lee, M. Kimura, P. M. O'Neill, P. G. Bray, S. A. Ward, S. Krishna, Artemisinins target the SERCA of Plasmodium falciparum Nature. ,vol. 424, pp. 957- 961 ,(2003) , 10.1038/NATURE01813
Henry C. Lai, Narendra P. Singh, Tomikazu Sasaki, Development of artemisinin compounds for cancer treatment Investigational New Drugs. ,vol. 31, pp. 230- 246 ,(2013) , 10.1007/S10637-012-9873-Z
Camilla Ricci, Leonard Nyadong, Felicia Yang, Facundo M Fernandez, Christopher D Brown, Paul N Newton, Sergei G Kazarian, Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry Analytica Chimica Acta. ,vol. 623, pp. 178- 186 ,(2008) , 10.1016/J.ACA.2008.06.007