Mesenchymal stem cells for repair of the airway epithelium in asthma

摘要: The airway epithelium is constantly faced with inflammatory and potentially injurious stimuli. Following damage, rapid repair mechanisms involving proliferation differentiation of resident progenitor stem cell pools are necessary in order to maintain a protective barrier. In asthma, evidence pointing compromised ability the properly regenerate rapidly accumulating. consequences this presently unknown but likely have significant impact on lung function. Mesenchymal cells potential serve as universal source for replacement specific several diseases thus offer hope therapeutic intervention treatment chronic remodeling changes that occur asthmatic epithelium. However, controversy exists regarding whether these can actually home engraft within airways contribute tissue function or mechanism necessary, since they potent paracrine...