CYP1A1, GSTT1, IL-6 and IL-8 transcription and IL-6 secretion on umbilical endothelial cells from hypertensive pregnant women: Preliminary results
作者： Sandra S. Reyes-Aguilar , Irais Poblete-Naredo , Yury Rodríguez-Yáñez , Rogelio O. Corona-Núñez , Christian D. Ortiz-Robles
DOI: 10.1016/J.PREGHY.2019.09.002
关键词: Internal medicine 、 Endocrinology 、 Endothelial stem cell 、 Medicine 、 Endothelial dysfunction 、 In utero 、 Umbilical vein 、 Interleukin 6 、 Offspring 、 Interleukin 8 、 Gestational hypertension
摘要: The impact of pregnancy hypertension in the offspring endothelia remains unknown. We evaluated transcriptional expression four genes that participate process endothelial dysfunction using umbilical vein cell cultures (HUVEC) from healthy pregnant women (PW) and those with hypertensive disorders (HD). cytochrome P450 1A1 (CYP1A1), gluthathione S-transferase subtype T1 (GSTT1), interleukin 6 (IL-6) 8 (IL-8) mRNA IL-6 protein levels were assessed. IL-8 transcripts significantly reduced HUVEC obtained HD women. Our results suggest a environment utero modifies key inflammatory molecules newborn.
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