Volume and shape analysis of subcortical brain structures and ventricles in euthymic bipolar I disorder.

摘要: Previous structural magnetic resonance imaging (S-MRI) studies of bipolar disorder have reported variable morphological changes in subcortical brain structures and ventricles. This study aimed to establish trait-related volumetric shape abnormalities a large, homogeneous sample prospectively confirmed euthymic I (BD-I) patients (n=60), compared with healthy volunteers (n=60). Participants were individually matched for age gender. Volume metrics derived from manually segmented S-MR images the hippocampus, amygdala, caudate nucleus, lateral Group differences analysed, controlling age, gender intracranial volume. BD-I displayed significantly smaller left hippocampal volumes larger ventricle controls. Shape analysis revealed an area contraction anterior head medial border as well expansion right tail medially, There no significant associations between volume or variation lithium status duration use. A reduction hippocampus is interesting, given this region's link verbal memory. ventricular indicated that these are not regionally specific.