Metabolism of the Viable Human Embryo

摘要: Regulation of energy production is fundamental to the survival and propagation any cell type. What makes preimplantation mammalian embryo so fascinating study fact that undergoes major changes in its physiology gene expression profiles during development. As fertilised oocyte develops differentiates into blastocyst, embryonic genes are successively turned on (with concomitant destruction maternally derived mRNAs). Subsequently there a growing demand as mitoses biosynthesis increase post-embryonic-genome activation blastocoel subsequently forms (through activity Na/K ATPase trophectoderm). Concomitantly, regulation relative activities generating pathways. Of clinical interest should an at stage development have substantially altered production, i.e. if flux specific nutrient through metabolic pathway alters significant degree, even for brief period, then this associated with significantly impaired culture reduction viability post-transfer. Clearly it our understand how regulates develop systems best support ‘optimal’ metabolism. Furthermore, evident analysis metabolism appropriate means assessing health predicting subsequent viability. The task ahead determine optimal range functions reflect successive stages