Orthotopic Liver Transplantation in the Rat: Survival Relationship Between Different Strain Combinations

摘要: Since the early days of organ transplantation, orthotopic liver transplantation (OLT) has been shown to not always obey rules immunology; grafts are often accepted without use immunosuppressive drugs in large animals [1–4], as was later demonstrated using genetically defined rats [5–7]. An extensive series OLT different donor-recipient combinations performed by Zimmermann [5, 8] and Kamada [9, 10]. These results clearly showed that fate is determined can be divided into following three groups, previously indicated [8, 11]: 1. High-responder combinations, which acute rejection occurs, with mean survival times 7–18 days 2. Intermediate-responder delayed between 30 50 days 3. Low-responder surviving more than 100 after