Ischemic injury leads to extracellular matrix alterations in retina and optic nerve.

摘要: Retinal ischemia occurs in a variety of eye diseases. Restrained blood flow induces retinal damage, which leads to progressive optic nerve degeneration and vision loss. Previous studies indicate that extracellular matrix (ECM) constituents play an important role complex tissues, such as retina nerve. They have great impact on de- regeneration processes represent major candidates central nervous system glial scar formation. Nevertheless, the importance ECM during ischemic neurodegeneration is not fully understood yet. In this study, we analyzed remodeling glycoproteins fibronectin, laminin, tenascin-C tenascin-R chondroitin sulfate proteoglycans (CSPGs) aggrecan, brevican phosphacan/RPTPβ/ζ retinae nerves ischemia/reperfusion rat model via quantitative real-time PCR, immunohistochemistry Western blot. A were dysregulated after ischemia. Regarding significantly elevated mRNA protein levels observed following ischemia, while laminin showed enhanced immunoreactivity Interestingly, CSPGs displayed increased expression Our study demonstrates dynamic molecules strengthens their regulatory neurodegeneration.