The Latest Clinical Findings for Yokukansan Based on Its Pharmacological Effects: Yokukansan Update

Izumi Kawagoe, Masanori Kanai, Yoshitaka Nakamura, Hiromasa Mitsuhata, Keiko Tajima, [Efficacy of traditional herbal medicine, Yokukansan on patients with neuropathic pain]. Masui. The Japanese journal of anesthesiology. ,vol. 58, pp. 1248- 1255 ,(2009)

Hideto Shinno, Mami Yamanaka, Ichiro Ishikawa, Sonoko Danjo, Yasushi Inami, Jun Horiguchi, Yu Nakamura, Successful treatment of restless legs syndrome with the herbal prescription Yokukansan Progress in Neuro-Psychopharmacology and Biological Psychiatry. ,vol. 34, pp. 252- 253 ,(2010) , 10.1016/J.PNPBP.2009.11.007

Tsuyoshi Miyaoka, Motohide Furuya, Liaury Kristian, Rei Wake, Kazunori Kawakami, Michiharu Nagahama, Kiminori Kawano, Masa Ieda, Keiko Tsuchie, Jun Horiguchi, Yi-Gan San for Treatment of Charles Bonnet Syndrome (Visual Hallucination Due to Vision Loss) Clinical Neuropharmacology. ,vol. 34, pp. 24- 27 ,(2011) , 10.1097/WNF.0B013E318206785A

Nobuaki Egashira, Katsunori Iwasaki, Ayumi Ishibashi, Kazuhide Hayakawa, Ryoko Okuno, Moe Abe, Naoki Uchida, Kenichi Mishima, Kotaro Takasaki, Ryoji Nishimura, Ryozo Oishi, Michihiro Fujiwara, Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex Progress in Neuro-psychopharmacology & Biological Psychiatry. ,vol. 32, pp. 1516- 1520 ,(2008) , 10.1016/J.PNPBP.2008.05.010

Z. Kawakami, H. Kanno, T. Ueki, K. Terawaki, M. Tabuchi, Y. Ikarashi, Y. Kase, Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells. Neuroscience. ,vol. 159, pp. 1397- 1407 ,(2009) , 10.1016/J.NEUROSCIENCE.2009.02.004

Kiyoshi Terawaki, Yasushi Ikarashi, Kyoji Sekiguchi, Yoichiro Nakai, Yoshio Kase, Partial agonistic effect of yokukansan on human recombinant serotonin 1A receptors expressed in the membranes of Chinese hamster ovary cells Journal of Ethnopharmacology. ,vol. 127, pp. 306- 312 ,(2010) , 10.1016/J.JEP.2009.11.003

Mark A. Edwards, Rhonda A. Loxley, Andrew J. Williams, Mark Connor, Jacqueline K. Phillips, Lack of functional expression of NMDA receptors in PC12 cells Neurotoxicology. ,vol. 28, pp. 876- 885 ,(2007) , 10.1016/J.NEURO.2007.04.006

Tsuyshi Miyaoka, Motohide Furuya, Hideaki Yasuda, Maiko Hayashia, Takuji Inagaki, Jun Horiguchi, Yi-gan san for the treatment of borderline personality disorder: an open-label study. Progress in Neuro-psychopharmacology & Biological Psychiatry. ,vol. 32, pp. 150- 154 ,(2008) , 10.1016/J.PNPBP.2007.07.026

Yasuyuki Suzuki, Hiromasa Mitsuhata, Mitsutoshi Yuzurihara, Yoshio Kase, Antiallodynic Effect of Herbal Medicine Yokukansan on Peripheral Neuropathy in Rats with Chronic Constriction Injury Evidence-based Complementary and Alternative Medicine. ,vol. 2012, pp. 953459- 953459 ,(2012) , 10.1155/2012/953459

Tsuyoshi Miyaoka, Motohide Furuya, Hideaki Yasuda, Maiko Hayashida, Akira Nishida, Takuji Inagaki, Jun Horiguchi, Yi-gan san as adjunctive therapy for treatment-resistant schizophrenia: an open-label study. Clinical Neuropharmacology. ,vol. 32, pp. 6- 9 ,(2009) , 10.1097/WNF.0B013E31817E08C3