Nuclear Receptor Function through Genomics: Lessons from the Glucocorticoid Receptor.

摘要: Unlocking the therapeutic potential of glucocorticoid receptor (GR) has motivated a search for small molecules that selectively modulate its ability to activate or repress gene transcription. Recently, breakthrough studies in field genomics have reinvigorated debate over longstanding transcriptional models explaining how GR controls tissue-specific expression. Here, we highlight these genomic with dual goals advancing understanding nuclear receptor-mediated transcription and stimulating thought on development anti-inflammatory immunosuppressive ligands reduced harmful effects metabolism.