The Neuroanatomy of Peduncular Hallucinosis: A Case Series and Lesion Overlap Analysis (S18.004)

摘要: OBJECTIVE: To better characterize the neuroanatomical substrate of peduncular hallucinosis (PH). BACKGROUND: PH refers to predominately visual hallucinations that occur in setting a midbrain or thalamic lesion. In 90 years have passed since Lhermitte9s initial description, phenomenology this disorder has been delineated over one hundred published cases. The precise anatomy PH, however, remains relatively understudied. ascending reticular activating system (ARAS) nuclei are commonly implicated, but large-scale anatomical analysis localize critical is lacking. DESIGN/METHODS: We synthesized lesion overlap map identify structures most lesioned cases PH. This mapping derived from local case series addition inclusion all previously include an figure demonstrating focal intrinsic brainstem diencephalon, excluding those with significant cortical involvement extrinsic compressive lesions (N=20). RESULTS: regions highest rostral midline mesencephalic tegmentum, region densely packed ARAS and reticulo-thalamic fibers, intralaminar complex, including mediodorsal centromedian-parafascicular nuclei. CONCLUSIONS: By neural involved we may understand mechanistic basis phenomenon. these findings lend insight into neurobiology other types and, more generally, how modulates content consciousness humans. Disclosure: Dr. Boes nothing disclose. Prasad Caviness