The Biological Effect of Dinitrosyl Iron Complexes with Glutathione upon Nitric Oxide Hyperproduction Induced by Endotoxin Shock
作者： A. A. Timoshin , V. L. Lakomkin , A. A. Abramov , A. F. Vanin , E. K. Ruuge
DOI: 10.1134/S0006350919010196
关键词: Endotoxin shock 、 Kidney 、 Biophysics 、 Inflammation 、 Biological effect 、 Nitric oxide 、 Ligand (biochemistry) 、 Rat model 、 Glutathione 、 Chemistry
摘要: Abstract—The objective of this work was to study the biological effect dinitrosyl iron complexes (DNICs) with glutathione ligand (GSH−DNICs) as a stabilized form nitric oxide in rat model hyperproduction induced by inflammation. Administration GSH−DNICs endotoxin shock did not increase total levels organs, but exerted protective suppressing liver and led an accumulation protein ligands kidney.
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