Exhaled breath condensate in pulmonary arterial hypertension

摘要: Over the last decade, several new agents have been developed for treatment of pulmonary arterial hypertension (PAH), and blood biomarkers which aim to monitor such treatment, correlate well with physiological parameters, symptoms mortality. However, little is known regarding collected using non-invasive methods as exhaled breath condensate (EBC). EBC show potential a rapid, repeatable easy method sampling vasculature in severely ill patients. The current study aimed investigate patients PAH different aetiologies. We studied 89 four groups: (PAH, n = 30), associated COPD (COPD/PAH, 14), but no (n 16) healthy controls 29). Levels following markers were measured: amino-terminal pro-brain natriuretic peptide (NT-proBNP), endothelin-1 (ET-1), 6-keto prostaglandin (PG)F(1α), hydrogen peroxide (H(2)O(2)), total oxides nitrogen (NO(x)), protein pH. ET-1 NT-proBNP measured plasma concurrently. Data analysed ANOVA or Kruskal Wallis tests where appropriate. Correlations performed Pearson's correlation coefficient. was detectable highest group, significantly higher than COPD/PAH group (194.1 ± 23.3 versus 80.8 22.2 fmol ml(-1), p < 0.05). subjects (1.53 0.32 ml(-1)) compared those (0.25 0.03 0.05) (0.66 0.18 PGF(1α) low lower (4027 445 8381 1024 pg 0.01). are measurable PAH. raised secondary COPD, whereas low. may be useful detection monitoring