Examining raphe-amygdala structural connectivity as a biological predictor of SSRI response

摘要: Abstract Background Our lab has previously found that structural integrity in tracts from the raphe nucleus (RN) to amygdala, measured by fractional anisotropy (FA), predicts remission selective serotonin reuptake inhibitors (SSRIs) major depressive disorder (MDD). This could potentially serve as a biomarker for can guide clinical decision-making. To enhance repeatability and reproducibility, we replicated our study larger, more representative multi-site sample. Methods 64 direction DTI was collected 144 medication-free patients with MDD Establishing Moderators Biosignatures of Antidepressant Response Clinical Care (EMBARC) study. We performed probabilistic tractography between RN bilateral amygdala hippocampus calculated weighted FA these tracts. Patients were treated either sertraline or placebo, their change Hamilton Depression Rating Scale (HDRS) score reported. Pretreatment compared remitters nonremitters, correlation percent HDRS assessed. Exploratory moderator voxel analyses also performed. Results Contrary hypotheses, greater nonremitters than RN-left right (p = 0.02 0.01, respectively). left correlated greater, not reduced, (r = 0.18, p = 0.04). finding be placebo group. Moderator yielded no significant findings. Conclusions remitters, symptom worsening, particularly placebo. These findings may help reveal about nature MDD, well research methods involving response.