Gamma knife radiosurgery in meningiomas of the posterior fossa. Experience with 62 treated lesions

摘要: OBJECTIVES This study was undertaken to assess the role of gamma knife (GK) in treatment meningiomas posterior cranial fossa (PCF) and statistically analyze predictability arbitrarily-selected prognostic factors such treatment. METHODS From February 1993 November 1998, 57 patients underwent GK for 62 PCF (19 M/38 F; average age, 57.5 years, ranging from 25 - 82 years). Tumor sites included: foramen jugular-petrous bone (26/62), petroclival (23/62), cerebellar convexity (6/62), tentorium magnum (1/62). Single lesions were treated 44/62 cases while meningiomatosis remaining 18. Post-operative residual or recurrent tumor found 27/62 and, 7/27, histology documented characteristics biological aggressiveness (GII/III). Indications radiosurgery advanced high operative risk, volume 5 ml). RESULTS The observation periods varied 6 64.3 months (median 28.7 months). At end study, 53/57 alive reported be stable improved neurological condition. cause death 4 2 deaths associated with progression, died due causes unrelated disease. Neuroradiological evaluation disappearance reduction meningioma mass 34/62 (55 %) cases, a imaging picture 25/62 (40 %), progression only 3/62 (5 %). To date, there have been no post-GK permanent morbidity mortality. Side effects observed transient nature post-radiosurgical edema (6.5 With regard statistical analysis, factor appear significantly influence efficacy growth control (TGC) (chi(2) = 2.708). presence meningiomatosis, SR as primary adjuvant nor shown behavior after GK. CONCLUSIONS excellent results obtained TGC minimal side suggest that is an effective therapeutic tool also meningiomas.