Risk Factors and Therapeutic Targets in Pancreatic Cancer

摘要: Pancreatic cancer (PC) is one of the most challenging tumor entities worldwide, characterized as a highly aggressive disease with dismal overall prognosis and an incidence rate equalling mortality rate. Over last decade, substantial progress has been made to define morphological changes key genetic events in pancreatic carcinogenesis. And yet, it still unclear what factors trigger PC. Some risk appear be associated sex, age, race/ethnicity, or other rare conditions. Additionally, modifying such smoking, obesity, diabetes, occupational factors, etc. increase potential for acquiring mutations that may result Another hallmark PC its poor response radio- chemotherapy. Current chemotherapeutic regimens could not provide survival benefit clear survival. Recently, several new approaches significantly improve clinical outcome have described involving downstream signalling cascades desmoplasia stromal well microenvironment, immune response, vasculature, angiogenesis. This review summarizes major tries illuminate relevant targets considerable therapeutic approaches.