The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control
作者： Yasukazu Nakahata , Milota Kaluzova , Benedetto Grimaldi , Saurabh Sahar , Jun Hirayama
DOI: 10.1016/J.CELL.2008.07.002
关键词: Circadian clock 、 ARNTL Transcription Factors 、 Chromatin 、 Biochemistry 、 Circadian rhythm 、 CLOCK Proteins 、 CLOCK 、 Biology 、 RAR-related orphan receptor alpha 、 Chromatin remodeling
摘要: Circadian rhythms govern a large array of metabolic and physiological functions. The central clock protein CLOCK has HAT properties. It directs acetylation histone H3 its dimerization partner BMAL1 at Lys537, an event essential for circadian function. We show that the HDAC activity NAD+-dependent SIRT1 enzyme is regulated in manner, correlating with rhythmic Lys9/Lys14 promoters. associates recruited to CLOCK:BMAL1 chromatin complex Genetic ablation Sirt1 gene or pharmacological inhibition lead disturbances cycle BMAL1. Finally, using liver-specific mutant mice we contributes control vivo. propose functions as enzymatic rheostat function, transducing signals originated by cellular metabolites clock.
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