Rearrangement in Stereoretentive Syntheses of Menthyl Chloride from Menthol: Insight into Competing Reaction Pathways through Component Quantification Analysis
作者： Lukas Hintermann , Kit Ming Wong
关键词: Organic chemistry 、 Chemistry 、 Nucleophilic substitution 、 Reaction mechanism 、 Chloride 、 Sigmatropic reaction 、 Enantiopure drug 、 Solvolysis 、 Carbenium ion 、 Reagent
摘要: The enantiopure reagent menthyl chloride (2) is generally prepared from (–)‐(1R)‐menthol (1) with Lucas' reagent (ZnCl2 in conc. aqueous HCl) in a stereoretentive reaction that …
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