The distribution, excretion and biotransformation of p-dichloro[14C]benzene in rats after repeated inhalation, oral and subcutaneous doses

摘要: 1. Following repeated daily whole-body exposure (3 h/day) of rats to atmospheres containing p-dichloro[14C]benzene (10000p.p.m.), or administration oral subcutaenous doses (250 mg/kg/day), 24-h tissue concn. 14C were similar and did not increase after six days dosing, but tended decrease. 2. After atmospheric exposures doses, highest occurred in fat, kidneys, liver lungs. Concn. declined rapidly near below limits detection (less than 0.2 p.p.m.) plasma tissues at 5 days. subcutaneous more slowly. 3. During five most excreted (91-97%) was the urine. Little faeces expired air. Excretion prolonged following administration. single bile duct-cannulated animals, 46-63% during 24 h. 4. The pattern metabolites urine each route although there quantitative differences. Urine extracts contained two major 14C-components, namely a sulphate glucuronide 2,5-dichlorophenol, representing 46-54% 31-34% urinary respectively. Two minor components identified by mass spectrometry as dihydroxydichlorobenzene mercapturic acid p-dichlorobenzene. 5. 2,5-dichlorphenol component (30-42%).