The effect of maternal Strongyloides venezuelensis infection on mice offspring susceptibility and immune response.

摘要: Abstract Species of Strongyloides infect a wide range hosts worldwide. Due to their complex life cycle, it is hard control the transmission these parasites. Several species show evidence vertical transmission; however, impact this route on susceptibility offspring has been poorly investigated. Herein, we used venezuelensis infected mice evaluate transplacental and transmammary parasite effect offspring. Swiss female were at end gestation or during breastfeeding period, examined for presence one week after infection mother. Our data showed that with S. did not transmit On other hand, all newborn in females got infected. To early exposure immune response hosts, each experimental group (non-infected, gestation-infected, breastfeeding-infected mothers) received anti-helminth treatment evaluation subcutaneously upon reaching adulthood. Mice from mothers lower adulthood comparison non-infected mothers. The low burden was accompanied by earlier eosinophil neutrophil activation gut higher serum levels IgE. In contrast, adult born gestation-infected presented more worms intestine parasite-reactive IgM mothers, thus suggesting antigens may modulate protective response. Altogether, our confirmed transmammary, but transplacental, demonstrated and/or an important host later infection.