HMQ‑T‑F2 suppresses migration of the human cervical cancer HeLa cells by reversing EMT via the PI3K/Akt signaling pathway.

摘要: Epithelial‑mesenchymal transition (EMT) is closely related to tumor metastasis, and offers insight into novel strategies for cancer treatment. HMQ‑T‑F2 (F2) a taspine derivative, which has excellent anticancer activity in human cervical cancer. The present study aimed evaluate the effect of F2 on vitro migration HeLa cells. data demonstrated that inhibited cells by negatively regulating Wnt signaling pathway reversing EMT. not only mediated Frizzled8, p‑LRP6 LRP6 expression, but also downregulated phosphorylation GSK3β, concurrently decreased nucleus protein expression MMP2, MMP3, MMP7, MMP9, c‑Myc. In addition, N‑cadherin, vimentin, Snail HIF‑1α were E‑cadherin was upregulated after associated with downregulation PI3K/Akt/mTOR pathways. Notably, induced cell accumulation at S phase apoptosis. These results provide evidence inhibits migration, proliferation promotes It reverses EMT, potentially via PI3K/Akt pathway. Therefore, may be potential therapeutic reagent against