A possible role of the plasmalemmal cytoskeleton, nitric oxide synthase, and innervation in infantile hypertrophic pyloric stenosis. A confocal laser scanning microscopic study.

摘要: In reference to a possible neuropathy in the pathogenesis of infantile hypertrophic pyloric stenosis (IHPS), previous studies have described alterations peptidergic transmission while others recently attributed an important role nitrinergic activity. Little attention has been given organization extracellular matrix (ECM) and constituent cytoskeleton subsarcolemma smooth-muscle cell. To study relationship between neuronal muscular elements IHPS, 9 biopsies from patients with IHPS 5 normal pylorus were examined using immunohistochemical techniques regard distribution nerve cells fibers (bNOS PGP 9.5) ECM (laminin) (talin, vinculin, dystrophin, α-smooth iso-actin, desmin) components muscle. Our results showed anti-protein gene product 9.5 b-nitric oxide synthase immunoreaction respectively reduced or absent positive reaction inside ganglion cells. An uneven component laminin was evident, together negative talin dystrophin. The imunolocalization desmin similar controls. findings suggest that there is close muscle pathophysiology non-alteration some can play regaining function after pyloromyotomy.