Mechanism of the interaction mediating killing of Schistosoma mansoni by human eosinophils.

摘要: Abstract Recent work on the role of eosinophils in immunity to Schistosoma mansoni is summarized. In vitro studies have shown that human can kill antibody-covered schistosomula. The killing mediated by associated with adherence these cells and subsequent degranulation release eosinophil major basic protein onto larvae. itself Antibody-dependent larvae proceeds at least two distinct steps. first Fc receptors relatively weak; second a temperature-dependent step which allows firm irreversible binding This stable eosinophils, process appears contribute preferential capacity this cell mediate antibody-dependent damage