Proteomic Analysis of Blood and Pancreatic Juice
作者： Mark Aspinall-O’Dea , John Neoptolemos , Eithne Costello
DOI: 10.1007/978-1-4419-1160-5_12
关键词: Biology 、 Drug activity 、 Drug development 、 Bioinformatics 、 Benign disease 、 Proteome 、 Cancer 、 Patient response 、 Pancreatic juice 、 Pancreatic cancer
摘要: The proteome is the complete set of proteins present in a defined cellular or extracellular compartment. A number studies have been undertaken to characterise protein profiles plasma/serum and pancreatic juice, differences between samples from cancer patients benign disease controls healthy individuals defined. More recently, advances liquid chromatography-mass spectrometry (LC-MS) instrumentation, as well developments quantitative proteomic approaches, analysis post-translational modifications enabled interrogation pathways effects drugs on those pathways. For targeted be used effectively, biomarkers that provide information regarding drug activity, toxicity patient response are essential. Such particularly useful if they can detected readily accessible, such plasma/serum. application techniques affords opportunities for discovering evaluating aid process development. In this chapter, some recent enable detection quantification blood juice will reviewed. Particular emphasis placed significance these novel treatments cancer.
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