Matrix metalloproteinases and diabetic vascular complications.

摘要: Diabetes mellitus (DM) is associated with an increased incidence of cardiovascular events and microvascular complications. These complications contribute to the morbidity mortality DM. There increasing evidence supporting a role for matrix metalloproteinases (MMPs) their inhibitors (tissue metalloproteinases—TIMPs) in atherosclerotic process. However, relationship between MMPs/TIMPs diabetic angiopathy less well defined. Hyperglycemia directly or indirectly (eg, via oxidative stress advanced glycation products) increases MMP expression activity. changes are histologic alterations large vessels. On other hand, low proteolytic activity MMPs contributes nephropathy. Within plaques imbalance TIMPs may induce degradation, resulting risk plaque rupture. Furthermore, because enhance blood coagulability, play ...