The effect of the Fusarium metabolite beauvericin on electromechanical and -physiological properties in isolated smooth and heart muscle preparations of guinea pigs.
作者： R. Lemmens-Gruber , B. Rachoy , E. Steininger , K. Kouri , P. Saleh
关键词: Membrane potential 、 Internal medicine 、 Chronotropic 、 Depolarization 、 Resting potential 、 Calcium 、 Beauvericin 、 Biology 、 Electrophysiology 、 Contractility 、 Endocrinology
摘要: The electromechanical and -physiological effects of beauvericin were studied in isolated smooth heart muscle preparations the guinea pig. Beauvericin concentration-dependently decreased force contraction precontracted (60 mM KCl) terminal ilea with an IC50 0.86 μM, electrically stimulated (1 Hz) papillary muscles 18 μM. This negative inotropic effect was antagonised a non-competitive way by increased extracellular calcium concentrations. Spontaneous activity right atria affected at concentrations >10 μM beauvericin. chronotropic less pronounced than effect. In action potentials driven muscles, 10 significantly membrane resting potential until unexcitability preparation occurred. Despite depolarisation maximum rate rise not changed. duration shortened, but decrease only significant times to 20% 50% repolarisation. These data, derived from electrophysiological experiments, imply on current as suggested contractility, also interaction sodium inward potassium outward currents.
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