Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation.

摘要: Key events ranging from cell polarity to proliferation regulation neuronal signaling rely on the assembly of multiprotein adhesion or complexes at particular subcellular sites. Multidomain scaffolding proteins nucleate and direct localization these complexes, protein Scribble its relatives in LAP family provide a paradigm for this. was originally identified because role apical–basal epithelial integrity Drosophila melanogaster. It is now clear that acts assemble position diverse processes planar oriented division synaptogenesis. Here, we explore what have learned about mechanisms action context multiple known interacting partners discuss how this knowledge opens new questions full range their structural roles.